Influence of fentanyl injection followed by infusion on intraocular pressure, pupil size and aqueous tear production in healthy non-painful dogs

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F19%3A43877481" target="_blank" >RIV/62157124:16170/19:43877481 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.17221/94/2019-VETMED" target="_blank" >https://doi.org/10.17221/94/2019-VETMED</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.17221/94/2019-VETMED" target="_blank" >10.17221/94/2019-VETMED</a>

Result language

angličtina

Original language name

Influence of fentanyl injection followed by infusion on intraocular pressure, pupil size and aqueous tear production in healthy non-painful dogs

Original language description

The goal of the presented research was to assess the influence of continuously administered fentanyl on the intraocular pressure, pupil size and aqueous tear production in dogs. A prospective, randomised, double ?blind? clinical study was performed. Twenty-five non-painful dogs, 13 breeds, a body weight of 10.0 ? 5.4 kg (mean ? SD) and age of 6.5 ? 3.3 years, 12 males and 13 females with no ocular abnormalities were randomly allocated into two groups receiving an intravenous injection of saline (SAL) 0.3 ml/kg followed by an infusion 2 ml/kg/h or an intravenous injection of fentanyl (FEN) 0.005 mg/kg (diluted in 0.3 ml/kg) followed by an infusion 0.005 mg/kg/h (diluted in 2 ml/kg/h). The intraocular pressure (IOP), pupil size (PS), pulse rate (PR), respiratory frequency (fR) and systolic and diastolic arterial pressures (SAP, DAP) were measured before (baseline) and at 2, 5, 10, 20 and 30 minutes after the premedication. The Schirmer Tear Test I (STT-I) was measured prior to and at 30 min after the premedication. The data were analysed by Bartlett?s, Anderson-Darling and Dunnett?s tests, the t-test and an analysis of variance (ANOVA) (P &lt; 0.05). Relative to the baseline, in the fentanyl group, the PS was significantly decreased at all time points, the PR was significantly decreased at T30 and the fR was significantly decreased at T5, T10, T20 and T30. There were no other significant changes in the IOP, STT-I, SAP and DAP relative to the baseline. Compared to the control group, in the fentanyl group, the PS was significantly smaller at T2, T5, T10, T20 and T30, the PR was significantly lower at T2, T20 and T30 and the fR was significantly higher at T20. Within thirty minutes of a constant rate infusion of fentanyl in the healthy non-painful dogs, the intraocular pressure and aqueous tear production were not affected. However, the fentanyl significantly decreased pupil size. This fact should be considered, when planning analgesia where miosis is undesirable.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

40301 - Veterinary science

Project

—

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Veterinární medicína

ISSN

0375-8427

e-ISSN

—

Volume of the periodical

64

Issue of the periodical within the volume

10

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

7

Pages from-to

449-455

UT code for WoS article

000493122800004

EID of the result in the Scopus database

2-s2.0-85075537107