Comparing the incidence of ventricular arrhythmias during epicardial ablation in swine versus canine models
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F19%3A43877781" target="_blank" >RIV/62157124:16170/19:43877781 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/19:00071024 RIV/00216224:14110/19:00112099
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/full/10.1111/pace.13698" target="_blank" >https://onlinelibrary.wiley.com/doi/full/10.1111/pace.13698</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/pace.13698" target="_blank" >10.1111/pace.13698</a>
Alternative languages
Result language
angličtina
Original language name
Comparing the incidence of ventricular arrhythmias during epicardial ablation in swine versus canine models
Original language description
Background Choosing the appropriate animal model for development of novel technologies requires an understanding of anatomy and physiology of these different models. There are little data about the characteristics of different animal models for the study of technologies used for epicardial ablation. We aimed to compare the incidence of ventricular arrhythmias during epicardial radiofrequency ablation between swine and canine models using novel epicardial ablation catheters. Methods We conducted a retrospective study using data obtained from epicardial ablation experiments performed on swine (Sus Scrofa) and canine (Canis familiaris) models. We compared the incidence of ventricular arrhythmias during ablation between swine and canine using multivariate regression analysis. Six swine and six canine animals underwent successful epicardial radiofrequency ablation. A total of 103 ablation applications were recorded. Results Ventricular arrhythmias requiring cardioversion occurred in 13.11% of radiofrequency ablation applications in swine and 9.75% in canine (relative risk: 117.6%, 95% confidence interval [CI]: 83.97-164.69, animal-based odds ratio [OR]: .55, 95% CI: .23-61.33; P = .184). When adjusting for application position, duration of ablation and power, the odds of developing potentially lethal ventricular arrhythmia in swine increased significantly compared to canine (OR: 3.60, 95% CI: 1.35-9.55; P = .010). Conclusions The swine myocardium is more susceptible to developing ventricular arrhythmias compared to canine model during epicardial ablation. This issue should be carefully considered in future studies.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
40301 - Veterinary science
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pace-pacing and clinical electrophysiology
ISSN
0147-8389
e-ISSN
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Volume of the periodical
42
Issue of the periodical within the volume
7
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
862-867
UT code for WoS article
000474649700012
EID of the result in the Scopus database
2-s2.0-85065207634