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The Accumulation and Effects of Liposomal Doxorubicin in Tissues Treated by Radiofrequency Ablation and Irreversible Electroporation in Liver: In Vivo Experimental Study on Porcine Models

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F19%3A43877782" target="_blank" >RIV/62157124:16170/19:43877782 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216224:14110/19:00108469 RIV/00216305:26220/19:PU133743 RIV/65269705:_____/19:00070868

  • Result on the web

    <a href="https://link.springer.com/content/pdf/10.1007%2Fs00270-019-02175-z.pdf" target="_blank" >https://link.springer.com/content/pdf/10.1007%2Fs00270-019-02175-z.pdf</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1007/s00270-019-02175-z" target="_blank" >10.1007/s00270-019-02175-z</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    The Accumulation and Effects of Liposomal Doxorubicin in Tissues Treated by Radiofrequency Ablation and Irreversible Electroporation in Liver: In Vivo Experimental Study on Porcine Models

  • Original language description

    PurposeTo compare the accumulation and effect of liposomal doxorubicin in liver tissue treated by radiofrequency ablation (RFA) and irreversible electroporation (IRE) in in vivo porcine models.Materials and MethodsSixteen RFA and 16 IRE procedures were performed in healthy liver of two groups of three pigs. Multi-tined RFA parameters included: 100W, target temperature 105 degrees C for 7min. 100 IRE pulses were delivered using two monopolar electrodes at 2250V, 1Hz, for 100 mu sec. For each group, two pigs received 50mg liposomal doxorubicin (0.5mg/kg) as a drip infusion during ablation procedure, with one pig serving as control. Samples were harvested from the central and peripheral zones of the ablation at 24 and 72h. Immunohistochemical analysis to evaluate the degree of cellular stress, DNA damage, and degree of apoptosis was performed. These and the ablation sizes were compared. Doxorubicin concentrations were also analyzed using fluorescence photometry of homogenized tissue.ResultsRFA treatment zones created with concomitant administration of doxorubicin at 24h were significantly larger than controls (2.50.3cm vs. 2.2 +/- 0.2cm; p=0.04). By contrast, IRE treatment zones were negatively influenced by chemotherapy (2.2 +/- 0.4cm vs. 2.6 +/- 0.4cm; p=0.05). At 24h, doxorubicin concentrations in peripheral and central zones of RFA were significantly increased in comparison with untreated parenchyma (0.431 +/- 0.078 mu g/g and 0.314 +/- 0.055 mu g/g vs. 0.18 +/- 0.012 mu g/g; p&lt;0.05). Doxorubicin concentrations in IRE zones were not significantly different from untreated liver (0.191 +/- 0.049 mu g/g and 0.210 +/- 0.049 mu g/g vs. 0.18 +/- 0.012 mu g/g).Conclusionsp id=Par4Whereas there is an increased accumulation of periprocedural doxorubicin and an associated increase in ablation zone following RFA, a contrary effect is noted with IRE. These discrepant findings suggest that different mechanisms and synergies will need to be considered in order to select optimal adjuvants for different classes of ablation devices.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    40301 - Veterinary science

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2019

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Cardiovascular and interventional radiology

  • ISSN

    0174-1551

  • e-ISSN

  • Volume of the periodical

    42

  • Issue of the periodical within the volume

    5

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    12

  • Pages from-to

    751-762

  • UT code for WoS article

    000462586800014

  • EID of the result in the Scopus database

    2-s2.0-85061585566