Evaluation of Tramadol Hydrochloride Toxicity to Juvenile Zebrafish-Morphological, Antioxidant and Histological Responses

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F20%3A43878779" target="_blank" >RIV/62157124:16170/20:43878779 - isvavai.cz</a>

Alternative codes found

RIV/62157124:16270/20:43878779

Result on the web

<a href="https://www.mdpi.com/2076-3417/10/7/2349" target="_blank" >https://www.mdpi.com/2076-3417/10/7/2349</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/app10072349" target="_blank" >10.3390/app10072349</a>

Result language

angličtina

Original language name

Evaluation of Tramadol Hydrochloride Toxicity to Juvenile Zebrafish-Morphological, Antioxidant and Histological Responses

Original language description

The presence of pharmaceuticals in water bodies is associated with the increasing consumption of these substances and limited elimination from wastewater. Pharmaceutical residues and their metabolites may have an unfavorable impact on fish and other aquatic biota. As the purification of wastewater from tramadol is very limited and the knowledge on its effects on non-target organisms is low, we decided to assess the subchronic impact of tramadol hydrochloride on fish-on the mortality, growth and histopathology, together with the impact on selected indices of oxidative stress. The juvenile growth toxicity test was carried out on zebrafish (Danio rerio), in accordance with the Organisation for European Economic Cooperation Guidelines 215 (Fish, Juvenile Growth Test). The fish were exposed to a range of tramadol hydrochloride concentrations (0.2, 2, 20, 200 and 600 mu g/L) for 28 days. The outcome of this study suggests that chosen concentrations of tramadol hydrochloride did not affect either mortality or growth (regarding weight, length and specific growth rate). However, the results of this study indicate that 28-day exposure can negatively influence selected indices of oxidative stress, which is a harmful imbalance between free radicals and antioxidants in an organism. A significant increase was observed in glutathione S-transferase activity in the experimental group exposed to 2 mu g/L tramadol hydrochloride, compared to the control. Moreover, lipid peroxidation was observed in groups exposed to 20 and 200 mu g/L, in comparison to the control.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10403 - Physical chemistry

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

APPLIED SCIENCES-BASEL

ISSN

2076-3417

e-ISSN

—

Volume of the periodical

10

Issue of the periodical within the volume

7

Country of publishing house

CH - SWITZERLAND

Number of pages

12

Pages from-to

—

UT code for WoS article

000533356200148

EID of the result in the Scopus database

—