Toxicity of naproxen sodium and its mixture with tramadol hydrochloride on fish early life stages

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081766%3A_____%2F17%3A00481103" target="_blank" >RIV/68081766:_____/17:00481103 - isvavai.cz</a>

Alternative codes found

RIV/62157124:16170/17:43875807 RIV/62157124:16270/17:43875807

Result on the web

<a href="http://dx.doi.org/10.1016/j.chemosphere.2017.08.151" target="_blank" >http://dx.doi.org/10.1016/j.chemosphere.2017.08.151</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.chemosphere.2017.08.151" target="_blank" >10.1016/j.chemosphere.2017.08.151</a>

Result language

angličtina

Original language name

Toxicity of naproxen sodium and its mixture with tramadol hydrochloride on fish early life stages

Original language description

Pharmaceuticals occur in water bodies as a consequence of their incomplete removal during waste water treatment processes. The occurence of pharmaceuticals in surface waters as well as their possible impact on aquatic vertebrates have received considerable attention in recent years. However, there is still a lack of informations on the chronic effects of widely used drugs as well as their possible mixture toxicity on non-target aquatic vertebrates as well as their possible mixture toxicity. The aim of this study was to assess the effects of naproxen sodium on early life stages of fish and evaluate its mixture toxicity with tramadol hydrochloride, which was assessed in our earlier study as a single substance. nnTwo embryo-larval toxicity tests with common carp (Cyprinus carpio) were performed according to the OECD guideline 210 (Fish, Early-life Stage Toxicity Test) in order to assess the subchronic toxicity of naproxen sodium and tramadol hydrochlorid-naproxen sodium mixture at the concentrations of 10, 50, 100 and 200 mu g/L. These experiments were conducted for 32 days. nnThe subchronic exposure to naproxen sodium and naproxen sodium and tramadol hydrochloride mixture had a strong effect on the early life stages of common carp. Hatching, developmental rate, morphology, histopathology and, in the case of the naproxen sodium and tramadol hydrochloride mixture, mortality were influenced. The bioindicators of oxidative stress were also influenced. The LOEC was determined at 10 mu g/L for both naproxen sodium and naproxen sodium and tramadol hydrochloride mixture.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10511 - Environmental sciences (social aspects to be 5.7)

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Chemosphere

ISSN

0045-6535

e-ISSN

—

Volume of the periodical

188

Issue of the periodical within the volume

December

Country of publishing house

GB - UNITED KINGDOM

Number of pages

10

Pages from-to

414-423

UT code for WoS article

000413378400045

EID of the result in the Scopus database

2-s2.0-85029007096