The effect of tramadol hydrochloride on early life stages of fish
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081766%3A_____%2F16%3A00460069" target="_blank" >RIV/68081766:_____/16:00460069 - isvavai.cz</a>
Alternative codes found
RIV/62157124:16170/16:43874357 RIV/62157124:16270/16:43874357
Result on the web
<a href="http://dx.doi.org/10.1016/j.etap.2016.05.006" target="_blank" >http://dx.doi.org/10.1016/j.etap.2016.05.006</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.etap.2016.05.006" target="_blank" >10.1016/j.etap.2016.05.006</a>
Alternative languages
Result language
angličtina
Original language name
The effect of tramadol hydrochloride on early life stages of fish
Original language description
The aim of this study was to perform the fish embryo acute toxicity test (FET) on zebrafish (Danio rerio) and the early-life stage toxicity test on common carp (Cyprinus carpio) with tramadol hydrochloride. The FET was performed using the method inspired by the OECD guideline 236. Newly fertilized zebrafish eggs were exposed to tramadol hydrochloride at concentrations of 10; 50; 100 and 200μg/l for a period of 144h. An embryo-larval toxicity test on C. carpio was performed according to OECD guideline 210 also with tramadol hydrochloride at concentrations 10; 50; 100 and 200μg/l for a period of 32 days. Hatching was significantly influenced in both acute and subchronic toxicity assays. Subchronic exposure also influenced early ontogeny, both morphometric and condition characteristics and caused changes in antioxidant enzyme activity. The LOEC value was found to be 10μg/l tramadol hydrochloride.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
GJ - Diseases and animal vermin, veterinary medicine
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Environmental Toxicology and Pharmacology
ISSN
1382-6689
e-ISSN
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Volume of the periodical
44
Issue of the periodical within the volume
June
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
7
Pages from-to
151-157
UT code for WoS article
000378184400020
EID of the result in the Scopus database
2-s2.0-84968796824