Are B-symptoms more reliable prognostic indicators than substage in canine nodal diffuse large B-cell lymphoma

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F21%3A43879268" target="_blank" >RIV/62157124:16170/21:43879268 - isvavai.cz</a>

Result on the web

<a href="https://onlinelibrary.wiley.com/doi/10.1111/vco.12661" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1111/vco.12661</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/vco.12661" target="_blank" >10.1111/vco.12661</a>

Result language

angličtina

Original language name

Are B-symptoms more reliable prognostic indicators than substage in canine nodal diffuse large B-cell lymphoma

Original language description

In humans B-symptoms refer to systemic symptoms of lymphoma such as fever, weight loss, and night sweats and influence the prognosis of patients. In canine lymphoma, substage B is used to describe any clinical sign observed. Aim of the retrospective study was to compare the prognostic value of substage B with B-symptoms to predict treatment response and survival in canine nodal diffuse large B-cell lymphoma. Affected dogs treated with CHOP chemotherapy between 2008 and 2019 were included. B-symptoms were defined by weight loss greater than 10% of normal weight, fever and the occurrence of unexplained resting tachypnoea substituted human night sweats. Substage B was defined as any symptoms but lymphadenopathy. Fifty-five cases were included. B-symptoms were present in 20/55 (36%) and substage B in 40/55 (74%) patients. No significant associations between B-symptoms or substage B and weight, sex, breed, WHO stage and lymphoma grade were found. Treatment response was negatively associated with both substage B (P = .02) and B-symptoms (P = .001). B-symptoms significantly decreased progression free survival (PFS) (95 vs 330 days, P = .001) and lymphoma specific survival (LSS) (160 vs 462 days, P = .001). Data showed that B-symptoms might be a more reliable prognostic indicator than substage B in canine nodal diffuse large B-cell lymphoma. Prospective studies assessing B-symptoms in a larger cohort of patients and in other common lymphoma types are warranted. The abstract was presented at the fourth meeting of the European Canine Lymphoma Network Group in Lugano, 22 June 2019 and published in the proceeding of the meeting on the page 26.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

40301 - Veterinary science

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Veterinary and Comparative Oncology

ISSN

1476-5810

e-ISSN

—

Volume of the periodical

19

Issue of the periodical within the volume

1

Country of publishing house

US - UNITED STATES

Number of pages

8

Pages from-to

201-208

UT code for WoS article

000591348500001

EID of the result in the Scopus database

2-s2.0-85096707785