Are B-symptoms more reliable prognostic indicators than substage in canine peripheral T-cell lymphoma?

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F19%3A43878127" target="_blank" >RIV/62157124:16170/19:43878127 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Are B-symptoms more reliable prognostic indicators than substage in canine peripheral T-cell lymphoma?

Original language description

B-symptoms refer to systemic clinical signs correlating with the worse prognosis of human lymphoma patients. In dogs, substage B is used to describe any clinical symptom observed. Preliminary data in canine nodal diffuse large B-cell lymphoma showed superiority of Bsymptoms over substage regarding prognostic accuracy. The aim of the retrospective study was to compare the accuracy of substage and B-symptoms to predict treatment response (TR) and survival in canine peripheral T-cell lymphoma (PTCL) between 2011-2019 treated with first-line CHOP or LOPP. B-symptoms were defined by weight loss exceeding 10% of normal weight, fever and unexplained resting tachypnea (instead of night sweats used in human medicine). Substage B was defined as any clinical signs except lymphadenomegaly. Twenty-two cases were included with B-symptoms present in ten (45%) and substage B in 18 (82%) patients. No significant association between B-symptoms or substage and weight, sex, breed, lymphoma stage and grade, and treatment were found. TR after induction chemotherapy was negatively associated with B-symptoms (P=0.02) but not with substage B (P=0.9). Patients with B-symptoms had a significantly shorter progression free survival (PFS) (32 vs. 133 days, P=0.002) and lymphoma specific survival (LSS) (63 vs. 186 days, P=0.002). In contrast substage B patients showed only a tendency toward shorter PFS (43 vs. 85 days, P=0.1) and LSS (94 vs. 205 days, P=0.06). According to our results, B-symptoms are a more reliable prognostic indicator than substage in canine PTCL. Due to the small sample size further studies are warranted to prove these results.

Czech name

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Czech description

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Type

O - Miscellaneous

CEP classification

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OECD FORD branch

40301 - Veterinary science

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů