Influence of methadone on intraocular pressure, pupil size and aqueous tear production in healthy dogs

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F22%3A43879946" target="_blank" >RIV/62157124:16170/22:43879946 - isvavai.cz</a>

Result on the web

<a href="https://reader.elsevier.com/reader/sd/pii/S1938973622001064?token=FE27FA7E26D800F86AF14DB2D5FD364BEB3B1E2A0A2B0502811EE4FC8534D76A32B37C18996944026DACE18B1C2D0C6D&originRegion=eu-west-1&originCreation=20230113132439" target="_blank" >https://reader.elsevier.com/reader/sd/pii/S1938973622001064?token=FE27FA7E26D800F86AF14DB2D5FD364BEB3B1E2A0A2B0502811EE4FC8534D76A32B37C18996944026DACE18B1C2D0C6D&originRegion=eu-west-1&originCreation=20230113132439</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.tcam.2022.100733" target="_blank" >10.1016/j.tcam.2022.100733</a>

Result language

angličtina

Original language name

Influence of methadone on intraocular pressure, pupil size and aqueous tear production in healthy dogs

Original language description

Intraocular pressure (IOP), pupil size (PS), and tear production are variables important in maintaining eye homeostasis.The purpose of this study was to determine the effects of methadone on IOP, PS, and tear production measured by Schirmer I tear test (STT-I) in healthy nonpainful dogs. A prospective, randomized, &quot;double-blind&quot; clinical study was performed. A total of 40 healthy conscious client-owned dogs were included in the study. Dogs were allocated randomly to 1 of 3 groups and given intravenous methadone 0.3 mg/kg (Met-IV, n=15), intramuscular methadone 0.3 mg/kg (Met-IM, n = 15), or saline 0.3 mL/kg (SAL, n = 10). IOP, PS, STT-I, heart rate (HR), and mean arterial pressure (MAP) weremeasured prior to (baseline) and at 2, 5, 10, 20, and 30 minutes after drug administration. Data were analyzed using 1-way and 2-way repeatedmeasures ANOVA or their nonparametric equivalents (P &lt; .05). No significant differences in IOP and PS within or between the groups were detected. In the Met-IV group, the STT-I decreased significantly after 30minutes (P = .025), however, the values remained within the physiological ranges. In Met-IV group, HR decreased significantly at 5, 10, 20, and 30 minutes, respectively. No other significant differences were observed.Methadone administered at a dose of 0.3 mg/kg intravenously or intramuscularly seems to cause within 30minutes no clinically important effect on IOP, PS, and STT-I in healthy conscious nonpainful dogs without ocular abnormalities.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

40301 - Veterinary science

Project

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Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Topics in Companion Animal Medicine

ISSN

1938-9736

e-ISSN

1946-9837

Volume of the periodical

51

Issue of the periodical within the volume

NOV 2022

Country of publishing house

US - UNITED STATES

Number of pages

5

Pages from-to

1-4

UT code for WoS article

000916654300007

EID of the result in the Scopus database

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