Genotyping Toxoplasma gondii: whole genome sequences of isolates across Europe reveal diversity within European type II strains
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F22%3A43880129" target="_blank" >RIV/62157124:16170/22:43880129 - isvavai.cz</a>
Alternative codes found
RIV/62157124:16170/22:43880147 RIV/62157124:16810/22:43880147
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Genotyping Toxoplasma gondii: whole genome sequences of isolates across Europe reveal diversity within European type II strains
Original language description
Toxoplasma gondii is a zoonotic protozoan parasite with an apparently largely clonal population structure in Europe. Few fine-scale typing methods exist for T. gondii. Whole genome sequence analysis of T. gondii offers new opportunities for the development of new discriminatory genotyping methods possibly with higher resolution and throughput for this parasite. We assessed the genomes of more than 70 T. gondii Type II isolates, including sequences of more than 60 European field isolates, by whole genome sequencing (WGS) and compared to the Type II reference strain Me49. Comparative analyses revealed up to four separate clusters of European type II T. gondii. The spatial distance between sites of isolation partially explained the detected genetic distance between isolates. We conclude that European T. gondii type II isolates are indeed genetically diverse. Based on our experiences, WGS may be useful to better understand the molecular epidemiology of the parasite in Europe, to trace infection sources in outbreaks and to detect the introduction of exotic or the emergence of recombinant strains.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
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OECD FORD branch
40301 - Veterinary science
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů