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Expression of Osteogenic Factors in FasL-Deficient Calvarial Cells

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F23%3A43880619" target="_blank" >RIV/62157124:16170/23:43880619 - isvavai.cz</a>

  • Result on the web

    <a href="https://www.biomed.cas.cz/physiolres/pdf/2023/72_117.pdf" target="_blank" >https://www.biomed.cas.cz/physiolres/pdf/2023/72_117.pdf</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.33549/physiolres.934945" target="_blank" >10.33549/physiolres.934945</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Expression of Osteogenic Factors in FasL-Deficient Calvarial Cells

  • Original language description

    During bone development, FasL acts not only through the traditional apoptotic mechanism regulating the amount of boneresorbing osteoclasts, but there is also growing evidence about its effect on cell differentiation. Expression of osteoblastic factors was followed in non-differentiated and differentiating primary calvarial cells obtained from FasL-deficient (gld) mice. The gld cells showed decreased expression of the key osteoblastic molecules osteocalcin (Ocn), osteopontin (Opn), and alkaline phosphatase (Alpl) in both groups. Notably, receptor activator of differentiated gld vs. wild type (wt) cells but decreased in differentiating gld cells. Osteoprotegerin (Opg) in the gld samples pathologies such as osteoporosis.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30105 - Physiology (including cytology)

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2023

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Physiological Research

  • ISSN

    0862-8408

  • e-ISSN

    1802-9973

  • Volume of the periodical

    72

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    CZ - CZECH REPUBLIC

  • Number of pages

    5

  • Pages from-to

    117-121

  • UT code for WoS article

    001000024200011

  • EID of the result in the Scopus database