Hydrolate of Helichrysum italicum Promotes Tissue Regeneration During Wound Healing
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F23%3A43881049" target="_blank" >RIV/62157124:16170/23:43881049 - isvavai.cz</a>
Result on the web
<a href="https://www.biomed.cas.cz/physiolres/pdf/2023/72_809.pdf" target="_blank" >https://www.biomed.cas.cz/physiolres/pdf/2023/72_809.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.33549/physiolres.935101" target="_blank" >10.33549/physiolres.935101</a>
Alternative languages
Result language
angličtina
Original language name
Hydrolate of Helichrysum italicum Promotes Tissue Regeneration During Wound Healing
Original language description
Wound healing is a dynamic process involving different cell types with distinct roles according to the stages of healing. Fibroblasts and stem cells actively participate in tissue regeneration. A proper stimulation could contribute to enhance wound healing processes. Helichrysum italicum (H. italicum) is a medical plant well described for its pharmacological, antimicrobial, and anti-inflammatory activities. Aim of the present work was to examine the effect of the hydrolate derivate from H. italicum on stem cells isolated from skin and fibroblasts in vitro in presence or absence of tissue damage. The viability and proliferation of all cell types cultured in different conditions were analyzed by MTT and BrdU assays. Cell proliferation after wound was analyzed with scratch test. Also, the expression of the main genes involved in tissue repair was evaluated by RT-qPCR analysis. Here we describe the capability of hydrolate of H. italicum to promote tissue regeneration after scratch test both in stem cells and in fibroblasts. Moreover, the gene expression analysis revealed that, hydrolate of H. italicum is also able to enhance stemness related. In conclusion our results are encouraging, highlighting novel regenerative properties of hydrolate of H. italicum and paving the way for future application of this wasting product in accelerating wound healing.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30105 - Physiology (including cytology)
Result continuities
Project
<a href="/en/project/LQ1601" target="_blank" >LQ1601: CEITEC 2020</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Physiological Research
ISSN
0862-8408
e-ISSN
1802-9973
Volume of the periodical
72
Issue of the periodical within the volume
6
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
10
Pages from-to
809-818
UT code for WoS article
001136613100025
EID of the result in the Scopus database
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