Effect of vatinoxan co-administered with medetomidine on intraocular pressure and pupil diameter in healthy dogs

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F25%3A43882278" target="_blank" >RIV/62157124:16170/25:43882278 - isvavai.cz</a>

Result on the web

<a href="http://chrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/https://vetmed.agriculturejournals.cz/pdfs/vet/2025/12/01.pdf" target="_blank" >http://chrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/https://vetmed.agriculturejournals.cz/pdfs/vet/2025/12/01.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.17221/47/2025-VETMED" target="_blank" >10.17221/47/2025-VETMED</a>

Result language

angličtina

Original language name

Effect of vatinoxan co-administered with medetomidine on intraocular pressure and pupil diameter in healthy dogs

Original language description

Medetomidine, an alpha-2 adrenoreceptor agonist, is used for sedation. This study aimed to determine the influence of the alpha-2 adrenoreceptor antagonist vatinoxan, co-administered with medetomidine, on healthy dogs’ intraocular pressure (IOP) and pupil diameter (PD). A prospective, randomised, masked clinical study was performed. A total of 40 conscious dogs were allocated to one of two groups: medetomidine 0.01 mg/kg with vatinoxan 0.2 mg/kg intravenously (MV-group, n = 20) or medetomidine 0.01 mg/kg intravenously (M-group, n = 20). The IOP, PD, heart rate, and mean arterial pressure were measured prior to baseline and 5, 10, and 20 min after drug administration. Data were analysed using one- and two-way repeated measures ANOVA or their non-parametric equivalents (P &lt; 0.05). No significant differences in IOP within or between groups were recorded. In the MV-group, PD remained unchanged compared to baseline. In the M-group, PD significantly (P = 0.007, P &lt; 0.001, P &lt; 0.001) decreased compared to baseline at all observation times. PD was significantly (P = 0.010, P &lt; 0.001, P &lt; 0.001) smaller in the M-group at all observation times compared to the MV-group. Vatinoxan co-administered with medetomidine, as well as medetomidine alone, did not significantly influence IOP. Vatinoxan with medetomidine did not affect PD, while medetomidine alone significantly reduced it.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

40301 - Veterinary science

Project

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Continuities

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Veterinární medicína

ISSN

0375-8427

e-ISSN

1805-9392

Volume of the periodical

70

Issue of the periodical within the volume

12

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

5

Pages from-to

427-431

UT code for WoS article

001654806700001

EID of the result in the Scopus database

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