Reversion to susceptibility of a carbapenem-resistant clinical isolate of Klebsiella pneumoniae producing KPC-3
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16270%2F13%3A43872434" target="_blank" >RIV/62157124:16270/13:43872434 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1093/jac/dkt235" target="_blank" >http://dx.doi.org/10.1093/jac/dkt235</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/jac/dkt235" target="_blank" >10.1093/jac/dkt235</a>
Alternative languages
Result language
angličtina
Original language name
Reversion to susceptibility of a carbapenem-resistant clinical isolate of Klebsiella pneumoniae producing KPC-3
Original language description
Objectives: We report the case of a kidney-transplant patient, suffering an intra-abdominal abscess at the surgical site caused by a carbapenem-resistant ST258 Klebsiella pneumoniae clone, producing the KPC-3 carbapenemase. Under tigecycline treatment, the patient developed a sepsis caused by a carbapenem-susceptible ST258 K. pneumoniae strain. Complete DNA sequences of the plasmids carried by the resistant and susceptible strains from this patient were determined. Methods: The complete DNA sequences ofplasmids were obtained by applying the 454 Genome Sequencer FLX-PLUS procedure on a library constructed of total plasmid DNA purified from the carbapenem-resistant and-susceptible strains. Results: In the carbapenem-resistant strain, four plasmids encoding 24 resistance genes, including bla(KPC-3), and two putative virulence clusters were detected. In the susceptible strain, large rearrangements occurred in the KPC-carrying plasmid, causing the deletion of the entire Tn4401::bla(KPC-3)
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EE - Microbiology, virology
OECD FORD branch
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Result continuities
Project
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Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Antimicrobial Chemotherapy
ISSN
0305-7453
e-ISSN
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Volume of the periodical
68
Issue of the periodical within the volume
11
Country of publishing house
GB - UNITED KINGDOM
Number of pages
5
Pages from-to
2482-2486
UT code for WoS article
000326978600012
EID of the result in the Scopus database
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