Effects of subchronic exposure of diclofenac on growth, histopathological changes, and oxidative stress in zebrafish (Danio rerio)

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16270%2F14%3A43872821" target="_blank" >RIV/62157124:16270/14:43872821 - isvavai.cz</a>

Alternative codes found

RIV/62157124:16170/14:43872821

Result on the web

<a href="http://dx.doi.org/10.1155/2014/645737" target="_blank" >http://dx.doi.org/10.1155/2014/645737</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1155/2014/645737" target="_blank" >10.1155/2014/645737</a>

Result language

angličtina

Original language name

Effects of subchronic exposure of diclofenac on growth, histopathological changes, and oxidative stress in zebrafish (Danio rerio)

Original language description

The aim of this study was to investigate effects of subchronic exposure to sublethal levels of diclofenac on growth, oxidative stress, and histopathological changes in Danio rerio. The juvenile growth tests were performed on Danio rerio according to OECDmethod number 215. Fish at the age of 20 days were exposed to the diclofenac environmental concentration commonly detected in the Czech rivers (0.02 mg L-1) and the range of sublethal concentrations of diclofenac (5, 15, 30, and 60 mg L-1) for 28 days.A significant decrease (P { 0.01) in the fish growth caused by diclofenac was observed in the concentrations of 30 and 60 mg L-1. The identified value of LOEC (lowest observed effect concentration) was 15 mg L-1 of diclofenac and NOEC (no observed effectconcentration) value was 5 mg L-1 of diclofenac. We did not find histopathological changes and changes of selected parameters of oxidative stress (glutathione S-transferase, glutathione reductase) in tested fish. The environmental concen

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

GJ - Diseases and animal vermin, veterinary medicine

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Scientific World Journal

ISSN

1537-744X

e-ISSN

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Volume of the periodical

2014

Issue of the periodical within the volume

2014

Country of publishing house

GB - UNITED KINGDOM

Number of pages

5

Pages from-to

"nestrankovano"

UT code for WoS article

000331475000001

EID of the result in the Scopus database

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