The effects of subchronic exposure to ciprofloxacin on zebrafish (Danio rerio)

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16270%2F14%3A43872883" target="_blank" >RIV/62157124:16270/14:43872883 - isvavai.cz</a>

Alternative codes found

RIV/62157124:16170/14:43872883

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

The effects of subchronic exposure to ciprofloxacin on zebrafish (Danio rerio)

Original language description

OBJECTIVES: The aim of this study was to assess the impact of ciprofloxacin in Danio rerio on growth, on the development of histopathological changes in selected organs (gills, kidney, liver), and on the activity of some oxidative stress markers during a 28-day toxicity test. METHODS: Juvenile growth tests were performed on D. rerio according to OECD guideline No. 215. Fish at the age of 30 days were exposed for 28 days to a range of concentrations of ciprofloxacin (0.7 ?g.L-1 - environmental concentration, 100, 650, 1 100 and 3 000 ?g.L-1). RESULTS: There were no significant differences between the specific growth rates of fish from the test groups and from the control group. Histopathological examination revealed no pathological changes in organs of fish exposed to any ciprofloxacin concentration. The activity of glutathione S-transferase increased at the ciprofloxacin concentrations of 0.7 and 100 ?g.L-1 compared to the control. A significant decrease in glutathione reductase activity was obtained in fish exposed to ciprofloxacin at 1 100 and 3 000 ?g.L-1; a significant decrease in glutathione peroxidase activity was also found, but at all tested concentrations except for 100 ?g.L-1. A decrease in the concentration of thiobarbituric acid reactive sub-stances was noted only at 100 ?g.L-1 compared to the control. CONCLUSIONS: According to our results, all tested concentrations of ciprofloxacin, including the environmental concentration, had an influence on oxidative stress markers and detoxifying enzymes in exposed fish, but did not affect fish growth or cause the development of histopathological changes in the fish organism.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

40301 - Veterinary science

Project

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Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neuroendocrinology Letters

ISSN

0172-780X

e-ISSN

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Volume of the periodical

35

Issue of the periodical within the volume

S2

Country of publishing house

US - UNITED STATES

Number of pages

7

Pages from-to

64-70

UT code for WoS article

000351064900008

EID of the result in the Scopus database

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