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Antimicrobial Properties of Microparticles Based on Carmellose Cross-Linked by Cu2+ Ions

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16270%2F15%3A43873515" target="_blank" >RIV/62157124:16270/15:43873515 - isvavai.cz</a>

  • Alternative codes found

    RIV/62157124:16170/15:43873515 RIV/62157124:16370/15:43873515

  • Result on the web

    <a href="http://dx.doi.org/10.1155/2015/790720" target="_blank" >http://dx.doi.org/10.1155/2015/790720</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1155/2015/790720" target="_blank" >10.1155/2015/790720</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Antimicrobial Properties of Microparticles Based on Carmellose Cross-Linked by Cu2+ Ions

  • Original language description

    Carmellose (CMC) is frequently used due to its high biocompatibility, biodegradability, and low immunogenicity for development of site-specific or controlled release drug delivery systems. In this experimental work, CMC dispersions in two different concentrations (1% and 2%) cross-linked by copper (II) ions (0.5, 1, 1.5, or 2.0 M CuCl2) were used to prepare microspheres with antimicrobial activity against Escherichia coli and Candida albicans, both frequently occurring pathogens which cause vaginal infections. The microparticles were prepared by an ionotropic gelation technique which offers the unique possibility to entrap divalent copper ions in a CMC structure and thus ensure their antibacterial activity. Prepared CMC microspheres exhibited sufficient sphericity. Both equivalent diameter and copper content were influenced by CMC concentration, and the molarity of copper (II) solution affected only the copper content results. Selected samples exhibited stable but pH-responsive behavio

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FR - Pharmacology and apothecary chemistry

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    S - Specificky vyzkum na vysokych skolach

Others

  • Publication year

    2015

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Biomed Research International

  • ISSN

    2314-6133

  • e-ISSN

  • Volume of the periodical

    Neuveden

  • Issue of the periodical within the volume

    2015

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    9

  • Pages from-to

    "Nestránkováno"

  • UT code for WoS article

    000355513200001

  • EID of the result in the Scopus database