Analysis of physiological parameters of Desulfovibrio strains from individuals with colitis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16270%2F18%3A43876487" target="_blank" >RIV/62157124:16270/18:43876487 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14310/18:00105404 RIV/62157124:16370/18:43876487

Result on the web

<a href="http://dx.doi.org/10.1515/biol-2018-0057" target="_blank" >http://dx.doi.org/10.1515/biol-2018-0057</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1515/biol-2018-0057" target="_blank" >10.1515/biol-2018-0057</a>

Result language

angličtina

Original language name

Analysis of physiological parameters of Desulfovibrio strains from individuals with colitis

Original language description

Intestinal sulfate-reducing bacteria are often isolated from patients with inflammatory bowel disease, including ulcerative colitis, and can be involved in the development of gut inflammation. A comparison of the metabolism of intestinal sulfate-reducing bacteria isolated from individuals with colitis and healthy controls using statistical analysis has never been studied and described before. The aim of our research was to evaluate the parameters of dissimilatory sulfate reduction in Desulfovibrio species that were isolated from the feces of healthy objects and individuals with colitis. Principal component analysis indicates that the strains that were isolated from individuals with colitis grouped in the same cluster by biomass accumulation and sulfide production, same as the strains isolated from healthy individuals. Sulfate and lactate consumption measured over time showed negative correlation (Pearson correlations, p&lt;0.01), healthy: -0.760; colitis: -0.770; healthy: -0.828; colitis: -0.847, respectively. The calculated linear regression (R2) was lower in biomass accumulation and hydrogen sulfide production, 0.531; 0.625 respectively. Thus, biomass accumulation and sulfide production, together with measured kinetic parameters play an important factor in bowel inflammation, including ulcerative colitis. Additionally, acetate production can also synergize with H2S, while sulfate consumption and lactate oxidation likely represent minor factors in bowel disease.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30304 - Public and environmental health

Project

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Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

OPEN LIFE SCIENCES

ISSN

2391-5412

e-ISSN

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Volume of the periodical

13

Issue of the periodical within the volume

1

Country of publishing house

PL - POLAND

Number of pages

8

Pages from-to

481-488

UT code for WoS article

000455227700001

EID of the result in the Scopus database

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