Determination of sulfonamides in honey: model study for method optimization

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16270%2F20%3A43878963" target="_blank" >RIV/62157124:16270/20:43878963 - isvavai.cz</a>

Result on the web

<a href="http://www.maso-international.cz/download/022019_83-89.pdf" target="_blank" >http://www.maso-international.cz/download/022019_83-89.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Determination of sulfonamides in honey: model study for method optimization

Original language description

The study was focused on optimization of methods for the determination of chemotherapeutics from the group of sulphonamides (sulfadiazine, sulfathiazole, sulfamethoxazole, sulfadoxin) in honey by liquid chromatography with tandem mass spectrometry (LC-MS/MS). Three working processes were selected for the optimization: water, acid hydrolysis 1, acid hydrolysis 2. The aim of the study was to determine a suitable methodology in which extraction of selected sulphonamides would be acceptable in terms of their physico-chemical properties. The model study was performed on a set of twelve parallel determinations at concentrations of 0.5, 1 and 5 ug/L for each procedure. The gained results indicated following analytical recoveries: from 79 % to 121 % (water), from 88 % to 127 % (acid hydrolysis 1) and from 61 % to 95 % (acid hydrolysis 2). The repeatability, expressed as relative standard deviation (RSD) was from 7.73 % to 29.60 % (water), from 4.37 % to 14.74 % (acid hydrolysis 1) and from 13.96 % to 31.58 % (acid hydrolysis 2). Regarding the phisico-chemical properties of sulphonamides, acid hydrolysis 2 was chosen as a suitable process.

Czech name

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Czech description

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Type

J_ost - Miscellaneous article in a specialist periodical

CEP classification

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OECD FORD branch

40301 - Veterinary science

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Maso International

ISSN

1805-5281

e-ISSN

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Volume of the periodical

9

Issue of the periodical within the volume

2

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

7

Pages from-to

83-89

UT code for WoS article

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EID of the result in the Scopus database

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