Effect of fluconazole and its metabolite 1,2,4 - triazole on the early developmental stages of the African clawed frog (Xenopus laevis)

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16270%2F25%3A43882704" target="_blank" >RIV/62157124:16270/25:43882704 - isvavai.cz</a>
Result on the web
<a href="https://obd.vfu.cz/fcgi/verso.fpl/_TS_/1773743217?fname=dload&idfile=3015076" target="_blank" >https://obd.vfu.cz/fcgi/verso.fpl/_TS_/1773743217?fname=dload&idfile=3015076</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Effect of fluconazole and its metabolite 1,2,4 - triazole on the early developmental stages of the African clawed frog (Xenopus laevis)
Original language description
This study investigated the developmental toxicity of fluconazole and 1,2,4-triazole on Xenopus laevis embryos using the FETAX (Frog Embryo Teratogenesis Assay – Xenopus) protocol. Embryos were exposed to three concentrations (1, 100, and 1000 μg/L) of each compound for the period of 120 hours. No significant mortality or delay in hatching was observed; however, FLU exposure led to a concentration-dependent increase in malformations, elevated heart rate, and increased body length, indicating higher developmental toxicity. TRIAZ showed significantly lower toxicity, with minimal effects observed only at the highest concentration. These findings highlight the environmental risks posed by pharmaceutical and pesticide residues, particularly azole compounds, to non-target aquatic organisms.
Czech name
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Czech description
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Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
XXVII. konference mladých vědeckých pracovníků s mezinárodní účastí: Sborník příspěvků
ISBN
978-80-7305-995-8
ISSN
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e-ISSN
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Number of pages
3
Pages from-to
68-70
Publisher name
Veterinární univerzita Brno
Place of publication
Brno
Event location
Brno
Event date
Jun 5, 2025
Type of event by nationality
EUR - Evropská akce
UT code for WoS article
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