Therapeutic use meets environmental concern: Gabapentin's toxicological profile in aquatic ecosystems-a review
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16270%2F25%3A43882706" target="_blank" >RIV/62157124:16270/25:43882706 - isvavai.cz</a>
Result on the web
<a href="https://actavet.vfu.cz/94/3/0231/" target="_blank" >https://actavet.vfu.cz/94/3/0231/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2754/avb202594030231" target="_blank" >10.2754/avb202594030231</a>
Alternative languages
Result language
angličtina
Original language name
Therapeutic use meets environmental concern: Gabapentin's toxicological profile in aquatic ecosystems-a review
Original language description
Gabapentin (GBP) is a widely prescribed antiepileptic and analgesic drug that has increasingly been detected in wastewater and surface water due to its incomplete metabolism and the fact that it is not efficiently removed by conventional wastewater treatment plants (WWTPs). Its persistence in the aquatic environment has raised concerns due to its possible impact on aquatic organisms. Typical environmental concentrations of GBP range from tens to hundreds of ng/l, with maximums of several mu g/l near WWTP effluents. While GBP is not acutely toxic at these amounts, sublethal effects have been observed in aquatic species, particularly in the zebrafish (Danio rerio), common carp (Cyprinus carpio) and the daphnids (Daphnia magna). Reported impacts include disrupted cardiovascular development, oxidative stress, apoptosis, altered gene expression related to immunity and neurodevelopment, and metabolic disturbances. In zebrafish embryos, concentrations of GBP as low as 0.1 mu g/l have been associated with enzymatic changes and vascular impairment. Efforts to mitigate the environmental impact of GBP include exploring advanced processing methods for removing GBP from wastewater, such as ozonisation. However, transformation products such as GBP-L may exhibit greater persistence and toxicity than the parent compound. Therefore, further research is urgently needed to understand the fate of GBP in the environment and to develop effective strategies for its removal and risk management. This comprehensive review highlights the dual significance of gabapentin, emphasising its therapeutic potential and the need to address its environmental implications for sustainable healthcare and ecological management.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
40301 - Veterinary science
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Acta veterinaria Brno
ISSN
0001-7213
e-ISSN
1801-7576
Volume of the periodical
94
Issue of the periodical within the volume
3
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
12
Pages from-to
231-242
UT code for WoS article
001600618100008
EID of the result in the Scopus database
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