Investigating the antiproliferative activity of quinoline-5,8-diones and styrylquinolinecarboxylic acids on tumor cell lines
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F07%3A00001114" target="_blank" >RIV/62157124:16370/07:00001114 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Investigating the antiproliferative activity of quinoline-5,8-diones and styrylquinolinecarboxylic acids on tumor cell lines
Original language description
The structure-activity relationships of new quinoline based compounds were investigated. Quinoline-5,8-dione and styrylquinoline scaffolds were used for the design of potentially active compounds. The novel analogues had comparable antiproliferative activity to cisplatin when evaluated in a bioassay against the P388 leukemia cell line. However, these compounds appeared far less efficient against SK-N-MC neuroepithelioma cells. Analogues without the 5,8-dione structure but containing the 8-carboxylic acid group were also found to induce antiproliferative activity. Hydrophobicity as measured by HPLC did not correlate with antiproliferative activity.
Czech name
Studium antiproliferativní aktivity chinolin-5,8-dionů a styrylchinolinkarboxylových kyselin na tumorových buněčných liniích
Czech description
Studovány byly vztahy mezi strukturou a aktivitou nových látek ? derivátů chinolinu. Chinolin-5,8-dionový a styrylchinolinový skelet byl použit pro design potenciálně účinných látek. Nové analogy měly antiproliferativní aktivitu stanovenou na leukemickébuněčná linii P388 srovnatelnou s cisplatinou, naproti tomu na buňkách neuroepiteliomu SK-N-MC se ukázaly jako neúčinné. Analogy neobsahující ketoskupiny v polohách 5 a 8, ale karboxyl v pol. 8, rovněž prokázaly schopnost navodit antiproliferativní účinek. Hydrofobita stanovená pomocí HPLC nekorelovala s antiproliferativní aktivitou.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2007
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Bioorganic and Medicinal Chemistry Letters
ISSN
0960-894X
e-ISSN
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Volume of the periodical
17
Issue of the periodical within the volume
22
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
4
Pages from-to
6138-6141
UT code for WoS article
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EID of the result in the Scopus database
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