Investigation of the Biological Properties of (Hetero)Aromatic Thiosemicarbazones

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F12%3A10133753" target="_blank" >RIV/00179906:_____/12:10133753 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11150/12:10133753 RIV/62157124:16370/12:43871096

Result on the web

<a href="http://dx.doi.org/10.3390/molecules171113483" target="_blank" >http://dx.doi.org/10.3390/molecules171113483</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/molecules171113483" target="_blank" >10.3390/molecules171113483</a>

Result language

angličtina

Original language name

Investigation of the Biological Properties of (Hetero)Aromatic Thiosemicarbazones

Original language description

Two series of thiosemicarbazone-based iron chelators (twenty-seven compounds) were designed and synthesized using a microwave-assisted approach. Quinoline and halogenated phenyl were selected as parent scaffolds on the basis of a similarity search. The lipophilicity of the synthesized compounds was measured using HPLC and then calculated. Primary in vitro screening of the synthesized compounds was performed against eight pathogenic fungal strains. Only a few compounds showed moderate activity against fungi, and (E)-2-(quinolin-2-ylvinyl)-N,N-dimethylhydrazine-carbothioamide appeared to be more effective than fluconazole against most of the fungal strains tested. Antiproliferative activity was measured using a human colon cancer cell line (HCT-116). Several of the tested compounds showed submicromolar antiproliferative activity. Compounds were also tested for their activity related to the inhibition of photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplast

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EE - Microbiology, virology

OECD FORD branch

—

Project

—

Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Molecules

ISSN

1420-3049

e-ISSN

—

Volume of the periodical

17

Issue of the periodical within the volume

11

Country of publishing house

CH - SWITZERLAND

Number of pages

20

Pages from-to

13483-13502

UT code for WoS article

000311428400075

EID of the result in the Scopus database

—