Contribution to investigation of antimicrobial activity of styrylquinolines

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F12%3A10133745" target="_blank" >RIV/00179906:_____/12:10133745 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11150/12:10133745 RIV/62157124:16370/12:43871087
Result on the web
<a href="http://dx.doi.org/10.1016/j.bmc.2012.10.027" target="_blank" >http://dx.doi.org/10.1016/j.bmc.2012.10.027</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.bmc.2012.10.027" target="_blank" >10.1016/j.bmc.2012.10.027</a>

Result language
angličtina
Original language name
Contribution to investigation of antimicrobial activity of styrylquinolines
Original language description
Series of new ring-substituted styrylquinolines and two oxorhenium complexes were prepared and characterized. The compounds were analyzed using RP-HPLC to determine lipophilicity. Primary in vitro screening of the synthesized compounds was performed against fungal and bacterial strains. Some compounds were active against bacteria at micromolar level and against fungi at submicromolar level. Compounds 5,7-dichloro-2-[2-(2-ethoxyphenyl)vinyl]quinolin-8-ol expressed excellent antifungal activity comparablewith or higher than the standard fluconazole as well as antibacterial activity against Staphylococcus strains comparable with or higher than the standards bacitracin, penicillin and ciprofloxacin. The structure-activity relationships are discussed.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EE - Microbiology, virology
OECD FORD branch
—

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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