Polar constituents of Ligustrum vulgare L. and their effect on lipoxygenase activity

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F11%3A10013295" target="_blank" >RIV/62157124:16370/11:10013295 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.2478/s11696-011-0015-4" target="_blank" >http://dx.doi.org/10.2478/s11696-011-0015-4</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2478/s11696-011-0015-4" target="_blank" >10.2478/s11696-011-0015-4</a>

Result language
angličtina
Original language name
Polar constituents of Ligustrum vulgare L. and their effect on lipoxygenase activity
Original language description
The present work summarizes results of isolation and identification of polar constituents of the methanolic extract of Ligustrum vulgare L. leaves and of the evaluation of inhibiting activity of selected isolates on rat lung cytosol fraction lipoxygenase. Six different compounds were isolated from the ethylacetate and butanol portions of the methanolic extract (hydroxytyrosol and its glucoside, ligustroflavon, oleuropein, acteoside, echinacoside). The inhibitory activity of oleuropein, echinacoside andthe water infusion of Ligustrum vulgare leaves tested on LOX was expressed as IC(50). Kinetic parameters (K (M), V (max)) and type of inhibition were determined. As the most effective in competitive inhibition of LOX, oleuropein was proved.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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