Oxycellulose Beads with Drug Exhibiting pH-Dependent Solubility
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F11%3A43870392" target="_blank" >RIV/62157124:16370/11:43870392 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1208/s12249-011-9696-9" target="_blank" >http://dx.doi.org/10.1208/s12249-011-9696-9</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1208/s12249-011-9696-9" target="_blank" >10.1208/s12249-011-9696-9</a>
Alternative languages
Result language
angličtina
Original language name
Oxycellulose Beads with Drug Exhibiting pH-Dependent Solubility
Original language description
The aim of this study was to develop novel hydrogel-based beads and characterize their potential to deliver and release a drug exhibiting pH-dependent solubility into distal parts of gastrointestinal (GI) tract. Oxycellulose beads containing diclofenac sodium as a model drug were prepared by the ionotropic external gelation technique using calcium chloride solution as the crosslinking medium. Resulting beads were characterized in terms of particle shape and size, encapsulation efficacy, swelling abilityand in vitro drug release. Also, potential drug-polymer interactions were evaluated using Fourier transform infrared spectroscopy. The particle size was found to be 0.92-0.96 mm for inactive (oxycellulose only) and 1.47-1.60 mm for active (oxycellulose-diclofenac sodium) beads, respectively. In all cases, the sphericity factor was between 0.70 and 0.81 with higher values observed for samples containing higher polymer and drug concentrations. The swelling of inactive beads was found to b
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/2A-1TP1%2F073" target="_blank" >2A-1TP1/073: *New pharmaceutical products based on polysaccharides</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
AAPS PHARMSCITECH
ISSN
1530-9932
e-ISSN
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Volume of the periodical
12
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
1348-1357
UT code for WoS article
000297586500036
EID of the result in the Scopus database
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