Investigation of antiradical activity of Salvia officinalis L., Urtica dioica L., and Thymus vulgaris L. extracts as potential candidates for a complex therapeutic preparation

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F11%3A43870420" target="_blank" >RIV/62157124:16370/11:43870420 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.5897/JMPR11.1177" target="_blank" >http://dx.doi.org/10.5897/JMPR11.1177</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5897/JMPR11.1177" target="_blank" >10.5897/JMPR11.1177</a>

Result language
angličtina
Original language name
Investigation of antiradical activity of Salvia officinalis L., Urtica dioica L., and Thymus vulgaris L. extracts as potential candidates for a complex therapeutic preparation
Original language description
The aim of this study was to investigate free radical-scavenging activity of Salvia officinalis L., Thymus vulgaris L., Urtica dioica L. extracts and mixture of extracts, and to evaluate the effect of these extracts on the ability of mitochondria to generate free radicals. The evaluation of the activity of extracts using 2,2-diphenyl-1-picrylhydrazyl (DDPH), 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonate) (ABTS) radicals scavenging assays and tyrosine nitration inhibition (TNI) techniques showed thatthyme extract had the strongest free-radical-scavenging activity. This extract was also found to contain the highest amount of phenols. Mixture of extracts showed slow and identical DPPH and ABTS radical-scavenging activity, with the strongest activitydemonstrated during the first minute. Investigation of the ability of extracts to neutralize hydrogen peroxide showed that the lowest extract amount used (0.01 mg) neutralized 24 to 50% and the highest amount (0.1 mg) - 72 to 88% of H(2)O
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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