5-Fluorouracil- Characteristics and Analytical Determination

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F11%3A43870808" target="_blank" >RIV/62157124:16370/11:43870808 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.2174/157341211794708767" target="_blank" >http://dx.doi.org/10.2174/157341211794708767</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2174/157341211794708767" target="_blank" >10.2174/157341211794708767</a>

Result language
angličtina
Original language name
5-Fluorouracil- Characteristics and Analytical Determination
Original language description
5-fluorouracil (5-FU or f5U) is a pyrimidine analogue, and is used as an antineoplastic drug. Working with antineoplastic drugs constitutes a health hazard for the people who handle them, mainly because of their mutagenicity, teratogenicity and carcinogenicity. This is the reason, why the determination of antineoplastic drugs in wipe samples obtained from the hospital departments, where antineoplastic drugs are prepared or administered is growing in importance. 5-fluorouracil has some unusual pharmacological characteristics, which make it suitable for therapeutic drug monitoring. Thus, its determination in plasma and other body fluids or in urine is important, too. Like other drugs, 5-fluorouracil is also determined in formulations during quality control or stability studies.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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