Stability testing of alginate-chitosan films

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F12%3A43871091" target="_blank" >RIV/62157124:16370/12:43871091 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Stability testing of alginate-chitosan films

Original language description

The pellets containing rutin prepared by extrusion/ spheronization method were coated with natrium alginate - chitosan film. Important quality parameters in pellets before the coating were determined, and after the coating dissolution profiles of the drug were evaluated in dissolution media of pH corresponding to the conditions in gastrointestinal tract. Samples of coated pellets were located in the boxes for stability testing under different conditions, i.e. 25 °C and 60 % of relative humidity (RH); 30°C and 65 % RH and 40 °C and 75 % RH. After 1, 3, 6, 9 and 12 months (or 1, 3 and 6 months), dissolution test was repeated and compared with the original profiles using similarity factors. All similarity factor values above 50 indicate excellent stability of alginate-chitosan films.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

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Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Česká a slovenská farmacie

ISSN

1210-7816

e-ISSN

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Volume of the periodical

61

Issue of the periodical within the volume

1-2

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

8

Pages from-to

26-33

UT code for WoS article

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EID of the result in the Scopus database

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