Use of Metabolomics for Monitoring Metabolic Responses Caused by Drug Administration 2. Application of Metabolomics in the Study of Metabolic Changes Induced by Drugs

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F12%3A43871553" target="_blank" >RIV/62157124:16370/12:43871553 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Use of Metabolomics for Monitoring Metabolic Responses Caused by Drug Administration 2. Application of Metabolomics in the Study of Metabolic Changes Induced by Drugs
Original language description
The aim of the paper is to present metabolomics as an effective tool for the study of responses of humans to drug treatment or animal models to drug administration. Generally, metabolomics can be used for monitoring disease status and drug efficacy, drugmetabolism, toxicity and drug-drug interactions. Attention is focused on different classes of drugs, and metabolite alterations caused by drug administration are analysed. Individual drugs are classified according to ATC groups. The selected drugs and pharmacotherapeutic groups were chosen according to their market share or potential. Antipsychotics, anti-inflammatory and antipyretic drugs, antihyperlipidemic agents, antiplatelet/anticoagulant drugs, antimicrobial chemotherapeutics, antineoplastic agents, immunosuppressants and contraceptives are discussed. In addition, the perspectives of the use of metabolomics for future drug discovery are outlined.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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