Cationic Eudragit Polymers as Excipients for Microparticles Prepared by Solvent Evaporation Method

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F13%3A43872056" target="_blank" >RIV/62157124:16370/13:43872056 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Cationic Eudragit Polymers as Excipients for Microparticles Prepared by Solvent Evaporation Method

Original language description

Three cationic acrylic polymers, i. e. Eudragit RL, Eudragit RS and Eudragit E 100 were evaluated for the purpose of microparticles preparation by the solvent evaporation method. Practically insoluble drug mirtazapine and freely soluble drug tramadol hydrochloride were selected for encapsulation as extreme limits of drug solubility. Prepared microspheres were analyzed by optical microscopy, drug content analysis and dissolution test. It was observed that Eudragit RL did not provide microparticles whileEudragit RS and Eudragit E 100 gave spherical microparticles. Samples prepared with mirtazapine showed sustained drug release whereas tramadol hydrochloride samples released the drug in a pattern similar to immediate release profile. Eudragit RS was found to be superior to Eudragit E 100 in its encapsulation efficiency, drug loading and smaller mean size of microparticles.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

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Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Česká a slovenská farmacie

ISSN

1210-7816

e-ISSN

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Volume of the periodical

62

Issue of the periodical within the volume

6

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

6

Pages from-to

249-254

UT code for WoS article

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EID of the result in the Scopus database

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