BASIC ESTERS OF meta-/para-ALKOXYPHENYLCARBAMIC ACID CONTAINING 4-(2-METHYL-/2-FLUOROPHENYL)PIPERAZIN-1-YL MOIETY AND THEIR ANTIMICROBIAL ACTIVITY

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F13%3A43872345" target="_blank" >RIV/62157124:16370/13:43872345 - isvavai.cz</a>

Result on the web

—

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

BASIC ESTERS OF meta-/para-ALKOXYPHENYLCARBAMIC ACID CONTAINING 4-(2-METHYL-/2-FLUOROPHENYL)PIPERAZIN-1-YL MOIETY AND THEIR ANTIMICROBIAL ACTIVITY

Original language description

The original esters of meta-/para-alkoxyphenylcarbamic acid containing 4-(2-methyl-/2-fluorophenyl)piperazin-1-yl, labelled as 5d-7d, were screened for their in vitro antimicrobial activity against Staphylococcus aureus, Escherichia coli and Candida albicans, respectively. Following the minimum inhibitory concentration (MIC) assay, electronic and hydrophobic interactions, induced by suitable substitution at the N-phenylpiperazine, ring have appeared to be more noticabe factors which positively influenced the efficiency of these compounds against S. aureus as well as against E. coli than relatively high lipophilicity of 5d-7d. In general, the compounds comprising methyl substituent attached to basic fragment (7a-7d) were observed to be more active against both given bacterial strains in the comparison to those with fluoro group (5d and 5e). From the entire analyzed set, the most active molecule 7b showed MIC=0.10 mg.mL(-1) against given Gram-positive and Gram-negative bacteria as well.

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

—

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Fresenius Environmental Bulletin

ISSN

1018-4619

e-ISSN

—

Volume of the periodical

22

Issue of the periodical within the volume

9A

Country of publishing house

DE - GERMANY

Number of pages

6

Pages from-to

2689-2694

UT code for WoS article

000326911800008

EID of the result in the Scopus database

—