STRUCTURE-ANTIMICROBIAL PROPERTIES STUDY OF SOME DIBASIC PHENYLCARBAMIC ACID ESTERS

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F16%3A43874622" target="_blank" >RIV/62157124:16370/16:43874622 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.14499/indonesianjpharm27iss1pp53" target="_blank" >http://dx.doi.org/10.14499/indonesianjpharm27iss1pp53</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.14499/indonesianjpharm27iss1pp53" target="_blank" >10.14499/indonesianjpharm27iss1pp53</a>

Result language

angličtina

Original language name

STRUCTURE-ANTIMICROBIAL PROPERTIES STUDY OF SOME DIBASIC PHENYLCARBAMIC ACID ESTERS

Original language description

Due to worldwide phenomenon of microbial resistance to commonly used therapeutic agents, antibiotics and antifungals, dibasic di-/trimethylphenylcarbamic acid esters 1-3, a non-traditional series of potential antimicrobials, has been in vitro evaluated against chosen gram-positive (Staphylococcus aureus) and gram-negative (Escherichia coli) bacterial strains as well as against yeast (C. albicans) by the minimum inhibitory concentration (MIC) assay. Taking into consideration chemical structure of tested derivatives, the incorporation of more than one protonated atom of nitrogen into salt forming fragment positively influenced the activity against E. coli. On the contrary, the presence of one or more methyl groups instead of 3-alkoxy side chain attached to lipophilic aromatic moiety has not found to be favorable structural feature. In entire set of inspected compounds, the most promising results have been found for the compound 3, chemically 1-[3-piperidinium-1-yl-2-({[(2,4,6-trimethylphenyl)amino]carbonyl}oxy)propyl]piperidinium dichloride, against E. coli with the MIC=1.56mg/mL.

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

—

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Indonesian journal of pharmacy

ISSN

2338-9427

e-ISSN

—

Volume of the periodical

27

Issue of the periodical within the volume

1

Country of publishing house

ID - INDONESIA

Number of pages

6

Pages from-to

53-58

UT code for WoS article

000378275600008

EID of the result in the Scopus database

—