Basic ortho-alkoxyphenylcarbamic acid esters containing variously substituted n-phenyl piperazine fragment and their antimicrobial activity

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F13%3A43872369" target="_blank" >RIV/62157124:16370/13:43872369 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Basic ortho-alkoxyphenylcarbamic acid esters containing variously substituted n-phenyl piperazine fragment and their antimicrobial activity

Original language description

Basic esters of ortho-alkoxyphenylcarbamic acid containing 4-(2-fluoro-/4-fluoro-/3-trifluoromethylphenyl)-piperazin-1-yI, 5a-8b, were screened for their in vitro antimicrobial activity against Escherichia coli, Candida albicans and Staphylococcus aureus, respectively. Following the minimum inhibitory concentration (MIC) assay, electronic and hydrophobic interactions, induced by suitable substitution at the N-phenylpiperazine ring, have appeared to be more notable factors which positively influenced theefficiency of such compounds against E. coli than the rising of their lipophilicity. Molecules comprising only of single atom of fluorine, 5a-6b, were observed to be more active (MIC=0.39-0.78 mg-mL-1) in the comparison to those with trifluromethyl group (MICs}1.00 mg-mL-1). On the contrary, the lipophilicity increasing of evaluated molecules accompanied by the presence of the substituent at N-phenylpiperazine with electron-withdrawing effect, 8a-8b, has positively reflected in their ef

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Fresenius Environmental Bulletin

ISSN

1018-4619

e-ISSN

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Volume of the periodical

22

Issue of the periodical within the volume

5a

Country of publishing house

DE - GERMANY

Number of pages

6

Pages from-to

1603-1608

UT code for WoS article

000319179200016

EID of the result in the Scopus database

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