Contribution to antimicrobial profile investigation of phenylcarbamic acid derivatives containing substituted N-phenylpiperazine fragment
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F12%3A43871063" target="_blank" >RIV/62157124:16370/12:43871063 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Contribution to antimicrobial profile investigation of phenylcarbamic acid derivatives containing substituted N-phenylpiperazine fragment
Original language description
The set of new original, higly lipophilic basic esters of phenylcarbamic acid containing 4-(2-fluoro-/4-fluorophenyl)piperazin-1-yl moiety, labelled as 1-12, was screened for in vitro antimicrobial activity against Escherichia coli, Candida albicans andStaphylococcus aureus, respectively. Following the minimum inhibitory concentration (MIC) assay by microdilution method, all tested molecules were against S. aureus, E. coli as well as C. albicans practically inactive. The study has revealed that the position of carbamate group have appeared to be the most notable factor which decisively influence the activity of tested compounds in the comparison with the importance of electronic or hydrophobic interactions induced by the substitution at the N-phenylpiperazine ring. Additionally, the lipophilicity rising had been regarded as relevant but not ultimate aspect for the effectiveness of these molecules. Finally it can be concluded that mandatory requirement for the activity maintenance agai
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Biological and Medical Research
ISSN
0976-6685
e-ISSN
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Volume of the periodical
3
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
4
Pages from-to
2531-2534
UT code for WoS article
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EID of the result in the Scopus database
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