Antimicrobial profile investigation of novel prospective ultra-short acting antagonists of beta-adrenergic receptors
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F14%3A43872704" target="_blank" >RIV/62157124:16370/14:43872704 - isvavai.cz</a>
Result on the web
—
DOI - Digital Object Identifier
—
Alternative languages
Result language
angličtina
Original language name
Antimicrobial profile investigation of novel prospective ultra-short acting antagonists of beta-adrenergic receptors
Original language description
Due to Worldwide phenomenon of microbial résistance to commonly used therapeutic agents, antibiotics and antifungals as well, a non-traditional séries of perspective ultra-short acting beta-adrenoceptor blockers, labelled as 1-4, has been in vitro evaluated against selected Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacterial strains as well as against yeast (C. albicans) by the minimum inhibitory concentration (MIC) assay. From chemical viewpoint, the présence of polar carboxy group within the structure of tested compounds has not found to be favourable structural feature because of its supposed splitting by the enzymes which have been produced by ail concerned microorganisms. On the other hand, within inspected set ofthe compounds, the increase in the lipophilicity has meant moderate improvement of the effectiveness against S. aureus and C. albicans, reaching the maximum for the most lipophilic substance 4 which has shown MIC=0.78 mg?mL-1 for given ba
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
—
Result continuities
Project
—
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Asian Journal of Microbiology, Biotechnology and Environmental Sciences
ISSN
0972-3005
e-ISSN
—
Volume of the periodical
16
Issue of the periodical within the volume
1
Country of publishing house
IN - INDIA
Number of pages
6
Pages from-to
1-5
UT code for WoS article
—
EID of the result in the Scopus database
—