Direct Effects of (-)-Epicatechin and Procyanidin B2 on the Respiration of Rat Heart Mitochondria

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F15%3A43873529" target="_blank" >RIV/62157124:16370/15:43873529 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1155/2015/232836" target="_blank" >http://dx.doi.org/10.1155/2015/232836</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1155/2015/232836" target="_blank" >10.1155/2015/232836</a>

Result language

angličtina

Original language name

Direct Effects of (-)-Epicatechin and Procyanidin B2 on the Respiration of Rat Heart Mitochondria

Original language description

Flavonol (-)-epicatechin and its derived dimer procyanidin B2, present in high amounts in cocoa products, have been shown to exert beneficial effects on the heart and cardiovascular system; however, their mechanism of action has not been fully elucidated. We studied effects of (-)-epicatechin and procyanidin B2 on the oxidative phosphorylation of isolated rat heart mitochondria. (-)-Epicatechin and procyanidin B2 had stimulating effect (up to 30% compared to control) on substrate-driven (State 2) mitochondrial respiration. Their effect was dependent on the respiratory substrates used. (-)-Epicatechin at higher concentrations (from 0.27 mu g/mL) significantly decreased (up to 15%) substrate-and ADP-driven (State 3) mitochondrial respiration in case of pyruvate and malate oxidation only. Procyanidin B2 (0.7-17.9 ng/mL) inhibited State 3 respiration rate up to 19%, the most profound effect being expressed with succinate as the substrate. (-)-Epicatechin at concentrations of 0.23 mu g/mL a

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomed Research International

ISSN

2314-6133

e-ISSN

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Volume of the periodical

Neuveden

Issue of the periodical within the volume

2015

Country of publishing house

US - UNITED STATES

Number of pages

7

Pages from-to

"Nestránkováno"

UT code for WoS article

000351098300001

EID of the result in the Scopus database

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