Olanzapine-depot administration induces time-dependent changes in adipose tissue endocrine function in rats

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F16%3A43874253" target="_blank" >RIV/62157124:16370/16:43874253 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/16:00090460

Result on the web

<a href="http://ac.els-cdn.com/S0306453016304930/1-s2.0-S0306453016304930-main.pdf?_tid=49040a32-ee2c-11e6-a600-00000aab0f27&acdnat=1486578645_c2d40e8878865eb7e281b9af708205eb" target="_blank" >http://ac.els-cdn.com/S0306453016304930/1-s2.0-S0306453016304930-main.pdf?_tid=49040a32-ee2c-11e6-a600-00000aab0f27&acdnat=1486578645_c2d40e8878865eb7e281b9af708205eb</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.psyneuen.2016.07.218" target="_blank" >10.1016/j.psyneuen.2016.07.218</a>

Result language

angličtina

Original language name

Olanzapine-depot administration induces time-dependent changes in adipose tissue endocrine function in rats

Original language description

Objective: Metabolic adverse effects of atypical antipsychotics (AAP) contribute significantly to increasedrisk of cardiovascular morbidity and mortality in patients suffering from schizophrenia. Extensive preclin-ical research has addressed this issue over the past years, though mechanisms underlying these adverseeffects of AAP are still not understood completely. Recently, attention is drawn towards the role of adiposetissue metabolism and neurohormonal regulations. Methods: The aim of this study was to evaluate the time-dependent effects of olanzapine depot adminis-tration at clinically relevant dosing on the regulation of energy homeostasis, glucose and lipid metabolism,gastrointestinal and adipose tissue-derived hormones involved in energy balance regulations in female Sprague-Dawley rats. The study lasted 8 weeks and the markers were assayed at day 8, 15, 29, 43 and 57. Results: The results indicate that in the absence of hyperphagia, olanzapine chronic exposure inducedweight gain from the beginning of the study. In the later time-point, increased adiposity was alsoobserved. In the initial phase of the study, lipid profile was altered by an early increase in triglyceridelevel and highly elevated leptin level was observed. Clear bi-phasic time-dependent effect of olanzapineon leptin serum concentration was demonstrated. Olanzapine treatment did not lead to changes in serumlevels of ghrelin, FGF-21 and pro-inflammatory markers IL-1a, IL-6 and TNF-alpha at any time-point of thestudy. Conclusion: This study provides data suggesting early alteration in adipose tissue endocrine function asa factor involved in mechanisms underlying metabolic adverse effects of antipsychotics.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

<a href="/en/project/LM2015090" target="_blank" >LM2015090: Czech National Node to the European Clinical Research Infrastructure Network</a><br>

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Psychoneuroendocrinology

ISSN

0306-4530

e-ISSN

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Volume of the periodical

73

Issue of the periodical within the volume

November

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

177-185

UT code for WoS article

000385324800021

EID of the result in the Scopus database

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