Polymorphism rs5498 of the ICAM-1 gene affects the progression of carotid atherosclerosis in patients with type 2 diabetes mellitus

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F16%3A43874493" target="_blank" >RIV/62157124:16370/16:43874493 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1186/s12944-016-0247-y" target="_blank" >http://dx.doi.org/10.1186/s12944-016-0247-y</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s12944-016-0247-y" target="_blank" >10.1186/s12944-016-0247-y</a>

Result language

angličtina

Original language name

Polymorphism rs5498 of the ICAM-1 gene affects the progression of carotid atherosclerosis in patients with type 2 diabetes mellitus

Original language description

Background: Adhesion molecules are involved in the development of atherosclerosis. An increased level of the ICAM 1 molecule is associated with numerous inflammatory diseases including atherosclerosis of carotid arteries. The rs5498 (K469E) polymorphism of the ICAM-1 gene leads to an increase in the level of serum ICAM. We investigated the association between the rs5498 (K469E) polymorphism of the ICAM-1 gene and the progression of carotid atherosclerosis in subjects with type 2 diabetes mellitus (T2DM). Methods: The study included 595 patients with T2DM and 200 subjects in the control group without T2DM. The control examination was made 3.8 years after the initial examination. Indicators of atherosclerosis (carotid intimamedia thickness (CIMT), total plaque sum and sum of the plaques thickness) were detected by ultrasound examination. Genetic analyses of the polymorphism rs5498 of the ICAM-1 gene were made by RT-PCR. Results: The distribution of genotypes and frequencies of rs5498 polymorphism was not significantly different between the group with type 2 diabetes (T2DM) and the control group. Genotype EE K469E polymorphism is associated with a statistically significant annual plaques growth. Conclusion: The EE genotype of the rs5498 of the ICAM-1 gene was associated with a more rapid progression of carotid atherosclerosis in patients with T2DM in comparison with other genotypes.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Lipids in Health and Disease

ISSN

1476-511X

e-ISSN

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Volume of the periodical

15

Issue of the periodical within the volume

April

Country of publishing house

GB - UNITED KINGDOM

Number of pages

7

Pages from-to

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UT code for WoS article

000374549700002

EID of the result in the Scopus database

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