Cimetidine Nanoparticles for Permeability Enhancement

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F16%3A43874584" target="_blank" >RIV/62157124:16370/16:43874584 - isvavai.cz</a>
Alternative codes found
RIV/61989100:27640/16:86097545 RIV/61989100:27740/16:86097545
Result on the web
<a href="http://dx.doi.org/10.1166/jnn.2016.12562" target="_blank" >http://dx.doi.org/10.1166/jnn.2016.12562</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1166/jnn.2016.12562" target="_blank" >10.1166/jnn.2016.12562</a>

Result language
angličtina
Original language name
Cimetidine Nanoparticles for Permeability Enhancement
Original language description
This article presents the preparation of cimetidine nanoparticles with macrogol 6000 as a stabilizer via liquid antisolvent precipitation method that were designed to enhance the permeation of the model drug through a membrane. Prepared nanoparticles were characterized by dynamic light scattering. The sample with particle size 194.5 nm was chosen as the most stable. Additionally, it was characterized by scanning electron microscopy and Fourier transform mid-infrared spectroscopy. The permeation of bulk and nanoparticle cimetidine was investigated using parallel artificial membrane permeability assay. It was found that cimetidine in nanoparticles permeated through the artificial membrane approximately in 10-fold higher concentration than bulk material.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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