Design and evaluation of mucoadhesive oral films containing sodium hyaluronate using multivariate data analysis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F17%3A43875624" target="_blank" >RIV/62157124:16370/17:43875624 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1080/10837450.2016.1194857" target="_blank" >http://dx.doi.org/10.1080/10837450.2016.1194857</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/10837450.2016.1194857" target="_blank" >10.1080/10837450.2016.1194857</a>
Alternative languages
Result language
angličtina
Original language name
Design and evaluation of mucoadhesive oral films containing sodium hyaluronate using multivariate data analysis
Original language description
Context: Mucoadhesive oral films, with their prolonged residence time at the site of application, offer a promising approach for protection of the oral lesion surface. The addition of sodium hyaluronate of different molecular weights as a second mucoadhesive polymer into the film matrix could positively influence the physico-mechanical and mucoadhesive properties of films. Objective: The aim of this study was to investigate the formulation of a monolayered film matrix containing varying amounts of sodium hyaluronate and to test the properties of such matrices by applying different characterization methods. Materials and methods: Film matrix was composed of two mucoadhesive polymers, carmellose sodium and sodium hyaluronate, plasticized with glycerol. Resulting films were characterized with regard to their viscosity and physico-mechanical properties. Results and discussion: Multivariate data analysis was employed to evaluate the influence of varying amounts of mucoadhesive polymers on the main mucoadhesive oral films' properties. The lower content of sodium hyaluronate caused improvements in mechanical properties and residence time on the artificial oral mucosa, both of which are the main characteristics that determine the quality of the final product. Conclusions: The best results were obtained by samples containing carmellose sodium with a small amount of sodium hyaluronate (about 0.5% in casting dispersion).
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
<a href="/en/project/NT14477" target="_blank" >NT14477: Modern Dosage Form for the Therapy of Oral Candidoses</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pharmaceutical development and technology
ISSN
1083-7450
e-ISSN
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Volume of the periodical
22
Issue of the periodical within the volume
2
Country of publishing house
GB - UNITED KINGDOM
Number of pages
8
Pages from-to
229-236
UT code for WoS article
000394648300013
EID of the result in the Scopus database
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