Evaluation of mucoadhesive oral films containing nystatin

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F16%3A43874418" target="_blank" >RIV/62157124:16170/16:43874418 - isvavai.cz</a>
Alternative codes found
RIV/62157124:16370/16:43874418
Result on the web
<a href="http://dx.doi.org/10.1016/j.jab.2016.05.002" target="_blank" >http://dx.doi.org/10.1016/j.jab.2016.05.002</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jab.2016.05.002" target="_blank" >10.1016/j.jab.2016.05.002</a>

Result language
angličtina
Original language name
Evaluation of mucoadhesive oral films containing nystatin
Original language description
The aim of the presented research was the preparation and in vitro and in vivo evaluation of mucoadhesive oral films containing nystatin. Multivariate data analysis was used to evaluate an innovative approach, in which a combination of different mucoadhesive polymers was employed. The purpose of this was to assess the effects of such a combination on nonwoven insoluble carmellose textile as a drug-release modifier in the structure of the film. It was observed that the mucoadhesive films prepared using polyethylene oxide were more plastic, showed less mechanical resistance and shorter in vitro residence time in comparison with films containing sodium carmellose. The textile used in films containing sodium carmellose significantly prolonged both in vitro and in vivo residence times in rabbits from 50 + 4 min until 74 + 4min and from 48 + 6 until 80 + 4 min, respectively. A higher degree of substitution by the acid carboxymethyl group of the textile resulted in slower nystatin dissolution, longer in vitro and in vivo residence times, and higher tensile strength. Textural parameters tensile strength and tensile deformation in conjunction with linear discriminant analysis were able to distinguish the degree of substitution of the textile due to its impact on the studied parameters.
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
—

Project
<a href="/en/project/NT14477" target="_blank" >NT14477: Modern Dosage Form for the Therapy of Oral Candidoses</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)