Evaluation of the influence of formulation and process variables on mechanical properties of oral mucoadhesive films using multivariate data analysis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F14%3A43873352" target="_blank" >RIV/62157124:16370/14:43873352 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1155/2014/179568" target="_blank" >http://dx.doi.org/10.1155/2014/179568</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1155/2014/179568" target="_blank" >10.1155/2014/179568</a>
Alternative languages
Result language
angličtina
Original language name
Evaluation of the influence of formulation and process variables on mechanical properties of oral mucoadhesive films using multivariate data analysis
Original language description
Oralmucosa is an attractive region for the local and systemic application of many drugs. Oral mucoadhesive films are preferred for their prolonged time of residence, the improved bioavailability of the drug they contain, their painless application, theirprotection against lesions, and their nonirritating properties. This work was focused on preparation of nonmedicated carmellose-based films using both solvent casting and impregnation methods, respectively. Moreover, a modern approach to evaluation of mucoadhesive films applying analysis of texture and subsequent multivariate data analysis was used. In this experiment, puncture strength strongly correlated with tensile strength and could be used to obtain necessary information about the mechanical filmcharacteristics in films prepared using both methods. Puncture work and tensile work were not correlated in films prepared using the solvent casting method, as increasing the amount of glycerol led to an increase in the puncture work in
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NT14477" target="_blank" >NT14477: Modern Dosage Form for the Therapy of Oral Candidoses</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biomed Research International
ISSN
2314-6133
e-ISSN
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Volume of the periodical
Neuveden
Issue of the periodical within the volume
2014
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
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UT code for WoS article
000340122800001
EID of the result in the Scopus database
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