Activity of ring-substituted 8-hydroxyquinoline-2-carboxanilides against intestinal sulfate-reducing bacteria Desulfovibrio piger
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F18%3A43876764" target="_blank" >RIV/62157124:16370/18:43876764 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14310/18:00102042
Result on the web
<a href="https://www.researchgate.net/publication/323108334_Effect_of_selected_8-hydroxyquinoline-2-carboxanilides_on_viability_and_sulfate_metabolism_of_Desulfovibrio_piger" target="_blank" >https://www.researchgate.net/publication/323108334_Effect_of_selected_8-hydroxyquinoline-2-carboxanilides_on_viability_and_sulfate_metabolism_of_Desulfovibrio_piger</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00044-017-2067-7" target="_blank" >10.1007/s00044-017-2067-7</a>
Alternative languages
Result language
angličtina
Original language name
Activity of ring-substituted 8-hydroxyquinoline-2-carboxanilides against intestinal sulfate-reducing bacteria Desulfovibrio piger
Original language description
Desulfovibrio genus is dominant among sulfate-reducing bacteria (SRB) in the large intestine of healthy people and animals. It is mostly isolated from patients with inflammatory bowel disease (IBD) and can be involved in the disease initiation. Primary in vitro screening of 8-hydroxyquinoline-2-carboxanilides was performed against Desulfovibrio piger Vib-7 representing SRB. The most effective compounds with MIC90/MBC values in the range of 17-23 mu M/20-23 mu M, respectively, were substituted in C'((3)) by CF3, OCH3, CH3 and in C'((4)) by CF3. Their activity was twofold higher than that of ciprofloxacin. These compounds did not express any significant cytotoxic effect on THP-1 cells up to the tested concentration of 30 mu M. The antibacterial efficacy of the most active C'((3))-substituted compounds practically did not change with increasing compound lipophilicity, indicating that this position of substitution is favorable for significant antimicrobial effect, while the antibacterial activity of most of C'((2)) and C'((4))-substituted derivatives decreased linearly with increasing compound lipophilicity. In addition, the dependence of activity on electronic Hammett's sigma parameter of the substituent R was quasi-parabolic for the most effective C'((3))-substituted compounds.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10606 - Microbiology
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Medicinal chemistry research
ISSN
1054-2523
e-ISSN
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Volume of the periodical
27
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
278-284
UT code for WoS article
000419972400025
EID of the result in the Scopus database
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