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Activity of ring-substituted 8-hydroxyquinoline-2-carboxanilides against intestinal sulfate-reducing bacteria Desulfovibrio piger

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F18%3A43876764" target="_blank" >RIV/62157124:16370/18:43876764 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216224:14310/18:00102042

  • Result on the web

    <a href="https://www.researchgate.net/publication/323108334_Effect_of_selected_8-hydroxyquinoline-2-carboxanilides_on_viability_and_sulfate_metabolism_of_Desulfovibrio_piger" target="_blank" >https://www.researchgate.net/publication/323108334_Effect_of_selected_8-hydroxyquinoline-2-carboxanilides_on_viability_and_sulfate_metabolism_of_Desulfovibrio_piger</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1007/s00044-017-2067-7" target="_blank" >10.1007/s00044-017-2067-7</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Activity of ring-substituted 8-hydroxyquinoline-2-carboxanilides against intestinal sulfate-reducing bacteria Desulfovibrio piger

  • Original language description

    Desulfovibrio genus is dominant among sulfate-reducing bacteria (SRB) in the large intestine of healthy people and animals. It is mostly isolated from patients with inflammatory bowel disease (IBD) and can be involved in the disease initiation. Primary in vitro screening of 8-hydroxyquinoline-2-carboxanilides was performed against Desulfovibrio piger Vib-7 representing SRB. The most effective compounds with MIC90/MBC values in the range of 17-23 mu M/20-23 mu M, respectively, were substituted in C&apos;((3)) by CF3, OCH3, CH3 and in C&apos;((4)) by CF3. Their activity was twofold higher than that of ciprofloxacin. These compounds did not express any significant cytotoxic effect on THP-1 cells up to the tested concentration of 30 mu M. The antibacterial efficacy of the most active C&apos;((3))-substituted compounds practically did not change with increasing compound lipophilicity, indicating that this position of substitution is favorable for significant antimicrobial effect, while the antibacterial activity of most of C&apos;((2)) and C&apos;((4))-substituted derivatives decreased linearly with increasing compound lipophilicity. In addition, the dependence of activity on electronic Hammett&apos;s sigma parameter of the substituent R was quasi-parabolic for the most effective C&apos;((3))-substituted compounds.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10606 - Microbiology

Result continuities

  • Project

  • Continuities

    S - Specificky vyzkum na vysokych skolach

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Medicinal chemistry research

  • ISSN

    1054-2523

  • e-ISSN

  • Volume of the periodical

    27

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    7

  • Pages from-to

    278-284

  • UT code for WoS article

    000419972400025

  • EID of the result in the Scopus database