Anti-inflammatory Activity of Various Phenolics

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F18%3A43876832" target="_blank" >RIV/62157124:16370/18:43876832 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Anti-inflammatory Activity of Various Phenolics
Original language description
Phenolics can be classified into several categories with the common structural moiety of phenolic hydroxyl. Their biological effects are often enhanced by so called prenylation, where the type of the prenyl connection and modification affects the bio-activity. This presentation would briefly summarize the effects of prenylated phenolics in vitro in cellular or biochemical systems on the production and release of inflammation-related cytokines; their effects on the inhibition of cyclooxygenases and lipoxygenases; the effects on the production of nitric oxide, an antiradical and antioxidant activity, and the effect on the inhibition of the release of enzymes and mediators from neutrophils, mast cells and macrophages. Some selected prenylated flavonoids, 2-arylbenzofurans, and stilbenes as potential antiphlogistic substances will be discussed in detail. The information about the antiphlogistic potential of prenylated phenolics gives the idea that a big pool of natural prenylated phenols represents a source of inspiration for synthesis, and that prenylated phenols are active principles of various medicinal plants used to combat inflammation.
Czech name
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Czech description
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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