Nitric oxide in the pathophysiology of retinopathy: evidences from preclinical and clinical researches
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F18%3A43877054" target="_blank" >RIV/62157124:16370/18:43877054 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1111/aos.13384" target="_blank" >http://dx.doi.org/10.1111/aos.13384</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/aos.13384" target="_blank" >10.1111/aos.13384</a>
Alternative languages
Result language
angličtina
Original language name
Nitric oxide in the pathophysiology of retinopathy: evidences from preclinical and clinical researches
Original language description
Retinopathy is the leading cause of blindness and visual disability in working-aged people. The pathogenesis of retinopathy is an actual and still open query. Alterations contributing to oxidative and nitrosative stress, including elevated nitric oxide and superoxide production, changes in the expression of different isoforms of nitric oxide synthase or endogenous antioxidant system, have been implicated in the mechanisms how this ocular disease develops. In addition, it was documented that renin-angiotensin system has been implicated in the progression of retinopathy. Based on comprehensive preclinical and clinical researches in this area, the role of above-mentioned factors in the pathogenesis of diabetic retinopathy, hypertensive retinopathy and ischaemic proliferative retinopathy is reviewed in this study. Moreover, the genetic susceptibility factors involved in the development of the retinopathy and possible strategies that utilize antioxidants as additive therapy are also highlighted here.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30107 - Medicinal chemistry
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Acta Ophthalmologica
ISSN
1755-375X
e-ISSN
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Volume of the periodical
96
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
222-231
UT code for WoS article
000430912700029
EID of the result in the Scopus database
2-s2.0-85017583112