Investigation of Permeation of Acyclovir through Skin Using Alaptide
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F18%3A43877069" target="_blank" >RIV/62157124:16370/18:43877069 - isvavai.cz</a>
Alternative codes found
RIV/68081715:_____/18:00478814
Result on the web
<a href="http://dx.doi.org/10.1556/1326.2017.00242" target="_blank" >http://dx.doi.org/10.1556/1326.2017.00242</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1556/1326.2017.00242" target="_blank" >10.1556/1326.2017.00242</a>
Alternative languages
Result language
angličtina
Original language name
Investigation of Permeation of Acyclovir through Skin Using Alaptide
Original language description
The investigation deals with the affection of the permeation of acyclovir through full-thickness pig ear skin using a Franz diffusion cell from the donor vehicles of phosphate buffer (pH 7.4) and propylene glycol-water (1: 1) using synthesised (S)-8-methyl-6,9-diazaspiro[4.5] decane-7,10-dione, alaptide as a transdermal permeation enhancer. Alaptide was applied in ratio 1:10 (w/w) relative to the amount of acyclovir. At the first hour after application, the permeated amount of acyclovir from propylene glycol-water system, simulating semisolid dosage forms, was ca. four-fold higher than from the formulation without alaptide. Despite that the enhancement ratio of alaptide in a steady state was 1.7, the pseudo-enhancement ratio of alaptide in the time range of first to third hour was 2.3. Both enhancement ratios indicate that alaptide modifies skin structure, while the short-term application of the alaptide formulation seems to be more advantageous.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30107 - Medicinal chemistry
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Acta chromatographica
ISSN
1233-2356
e-ISSN
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Volume of the periodical
30
Issue of the periodical within the volume
1
Country of publishing house
HU - HUNGARY
Number of pages
4
Pages from-to
62-65
UT code for WoS article
000428083500011
EID of the result in the Scopus database
2-s2.0-85045944718