Rapid Informative Screening of Nano-Alaptide as Potential Transdermal Permeation Enhancer of Acetylsalicylic Acid and Paracetamol.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F14%3A43873239" target="_blank" >RIV/62157124:16370/14:43873239 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Rapid Informative Screening of Nano-Alaptide as Potential Transdermal Permeation Enhancer of Acetylsalicylic Acid and Paracetamol.
Original language description
This investigation deals with the affection of permeation of acetylsalicylic acid and paracetamol applied in the system propylene glycol-water 1:1 through full-thickness pig ear skin by alaptide that was applied in nanonized form as a potential chemicalpenetration enhancer. Alaptide, (S)-8-methyl-6,9- diazaspiro[4.5]decan-7,10-dione, is the original Czech compound. The application of nanonized alaptide significantly enhanced the permeation of both drugs through the skin. Enhancement ratios in the studied time interval 0.5-2.0 h varied from 1.11 to 17.70 for acetylsalicylic acid and from 6.83 to 19.83 for paracetamol.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GAP304%2F11%2F2246" target="_blank" >GAP304/11/2246: Nanotechnology Approaches for Drug Delivery Across Blood-Tissue Barriers</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Vojenské zdravotnické listy - Military Medical Science Letters
ISSN
0372-7025
e-ISSN
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Volume of the periodical
83
Issue of the periodical within the volume
1
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
6
Pages from-to
34-39
UT code for WoS article
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EID of the result in the Scopus database
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