Rapid Screening of Mupirocin Skin Permeation Modification by Micronized and Nanonized Alaptide

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F14%3A43873238" target="_blank" >RIV/62157124:16370/14:43873238 - isvavai.cz</a>

Result on the web

<a href="http://pub.iapchem.org/ojs/index.php/admet/article/download/26/48" target="_blank" >http://pub.iapchem.org/ojs/index.php/admet/article/download/26/48</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5599/admet.2.1.26" target="_blank" >10.5599/admet.2.1.26</a>

Result language

angličtina

Original language name

Rapid Screening of Mupirocin Skin Permeation Modification by Micronized and Nanonized Alaptide

Original language description

The investigation deals with the affection of permeation of mupirocin from the Bactroban(R) Leciva ointment through full-thickness pig ear skin by alaptide that was applied in micronized or nanonized form as a potential excipient. Alaptide, (S)-8-methyl-6,9-diazaspiro[4.5]decan-7,10-dione, was the original Czech compound. It was discovered that micronized alaptide significantly enhanced the permeation of mupirocin within 1 h after administration (approx. 5-fold). On the other hand, nanonized alaptide almost completely inhibited permeation of mupirocin from Bactroban(R) Leciva through the skin. Rapid primary screening showed that the two forms of alaptide differently influenced the depth and the rate of permeation/penetration of mupirocin into/through the skin, i.e., affect curative effect of mupirocin on/in skin immediately after application of drug formulation.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

<a href="/en/project/GAP304%2F11%2F2246" target="_blank" >GAP304/11/2246: Nanotechnology Approaches for Drug Delivery Across Blood-Tissue Barriers</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

ADMET & DMPK

ISSN

1848-7718

e-ISSN

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Volume of the periodical

2

Issue of the periodical within the volume

1

Country of publishing house

HR - CROATIA

Number of pages

7

Pages from-to

56-62

UT code for WoS article

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EID of the result in the Scopus database

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