In Vitro Permeation of Micronized and Nanonized Alaptide from Semisolid Formulations

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F13%3A43872238" target="_blank" >RIV/62157124:16370/13:43872238 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1155/2013/787283" target="_blank" >http://dx.doi.org/10.1155/2013/787283</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1155/2013/787283" target="_blank" >10.1155/2013/787283</a>

Result language

angličtina

Original language name

In Vitro Permeation of Micronized and Nanonized Alaptide from Semisolid Formulations

Original language description

This study is focused on in vitro permeation of the original Czech compound, a skin/mucosa tissue regeneration promoter, known under the international nonproprietary name "alaptide," in micronized and nanonized forms. Alaptide showed a great potential for local applications for treatment and/or regeneration of the injured skin. The above mentioned technological modifications influence the permeation of alaptide through artificial or biological membranes, such as PAMPA or skin. The permeation of micronized and nanonized form of alaptide formulated to various semisolid pharmaceutical compositions through full-thickness pig ear skin using a Franz cell has been investigated in detail. In general, it can be concluded that the nanonized alaptide permeated through the skin less than the micronized form; different observations were made for permeation through the PAMPA system, where the micronized form showed lower permeation than the nanonized alaptide.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

<a href="/en/project/GAP304%2F11%2F2246" target="_blank" >GAP304/11/2246: Nanotechnology Approaches for Drug Delivery Across Blood-Tissue Barriers</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Scientific World Journal

ISSN

1537-744X

e-ISSN

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Volume of the periodical

neuveden

Issue of the periodical within the volume

2013

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

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UT code for WoS article

000329048400001

EID of the result in the Scopus database

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